Cannabis or medical marijuana has been used in the treatment of migraines for quite a long time. Cannabis has been a well documented remedy for this condition. Throughout the latter half of the nineteenth century, many prominent physicians in Europe and North America advocated the use of cannabis extracts for the symptomatic and preventative treatment of headaches. To this day there still remains a lack of controlled clinical studies using medical marijuana as a treatment method for migraines. However, there is an abundance of anecdotal evidence on the effective use of cannabis in the treatment of migraines.

The cannabinoids found in medical grade marijuana have been shown to have properties such as dopamine-blocking and anti-inflammatory effects. This would suggest that they may be useful in treating migraines.